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Cytochrome P450 2D6: Structure, Function, Regulation and by Shufeng Zhou

By Shufeng Zhou

Cytochromes are proteins that catalyze electron move reactions of famous metabolic pathways and are categorised in a number of superfamilies. The CYP, or P450, superfamily money owed for ninety% of the oxidative metabolism of medical medicinal drugs. One member of this superfamily, P450 2D6 (or CYP2D6), singlehandedly metabolizes approximately 25% of all drugs within the human liver. Cytochrome P450 2D6: constitution, functionality, law, and Polymorphism experiences the present wisdom of CYP2D6 in addition to the maturing physique of facts indicating its value to medical and pharmacological researchers and practitioners.

This booklet makes a speciality of the serious function CYP2D6 performs within the human liver. It examines the genetic, epigenetic, physiological, pathological, and structural components of the gene that govern the hugely variable metabolism of a few medications in scientific use. It highlights the influence of the sensible roles of CYP2D6 on scientific perform and drug improvement and likewise discusses implications for unique drugs, concepts to prevent antagonistic drug reactions, and paths for destiny research.

Cytochrome P450 2D6 is a distinct, priceless booklet targeting a unmarried yet immensely strong human gene. It presents the 1st unmarried resource of finished details on CYP2D6 that serves as an incredible reference for scientific, biomedical, pharmaceutical, and nursing researchers, practitioners, and students.

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