Skip to content

Cytochrome P450 2D6: Structure, Function, Regulation and by Shufeng Zhou

By Shufeng Zhou

Cytochromes are proteins that catalyze electron move reactions of famous metabolic pathways and are categorised in a number of superfamilies. The CYP, or P450, superfamily money owed for ninety% of the oxidative metabolism of medical medicinal drugs. One member of this superfamily, P450 2D6 (or CYP2D6), singlehandedly metabolizes approximately 25% of all drugs within the human liver. Cytochrome P450 2D6: constitution, functionality, law, and Polymorphism experiences the present wisdom of CYP2D6 in addition to the maturing physique of facts indicating its value to medical and pharmacological researchers and practitioners.


This booklet makes a speciality of the serious function CYP2D6 performs within the human liver. It examines the genetic, epigenetic, physiological, pathological, and structural components of the gene that govern the hugely variable metabolism of a few medications in scientific use. It highlights the influence of the sensible roles of CYP2D6 on scientific perform and drug improvement and likewise discusses implications for unique drugs, concepts to prevent antagonistic drug reactions, and paths for destiny research.


Cytochrome P450 2D6 is a distinct, priceless booklet targeting a unmarried yet immensely strong human gene. It presents the 1st unmarried resource of finished details on CYP2D6 that serves as an incredible reference for scientific, biomedical, pharmaceutical, and nursing researchers, practitioners, and students.

Show description

Read or Download Cytochrome P450 2D6: Structure, Function, Regulation and Polymorphism PDF

Similar cell biology books

Autophagy: Lower Eukaryotes and Non-Mammalian Systems, Part A: Lower Eukaryotes and Non Mammalian Systems: 451 (Methods in Enzymology)

This is often the significant other quantity to Daniel Klionsky’s Autophagy: reduce Eukaryotes, which beneficial properties the elemental tools in autophagy protecting yeasts and substitute fungi. Klionsky is without doubt one of the prime specialists within the box. he's the editor-in-chief of Autophagy. The November 2007 factor of Nature stories highlighted his article, “Autophagy: from phenomenology to molecular knowing in under a decade.

Experimental Hematology Today—1989: Selected Papers from the 18th Annual Meeting of the International Society for Experimental Hematology, July 16–20, 1989, Paris, France

Experimental Hematology this day - 1989 includes chosen papers offered on the 18th Annual assembly of the overseas Society for Experimental Hematology, July 16-20, 1989, Paris, France. 4 significant parts of study are explored: current elements of stem mobile transplantation; keep watch over of hemopoiesis; hemopoiesis in malignancies; and gene move.

Role of Proteases in Cellular Dysfunction: 8 (Advances in Biochemistry in Health and Disease)

It's now popular that proteases are came upon all over the place, in viruses and micro organism in addition to in all human, animal and plant cells, and play a task in a number of organic features starting from digestion, fertilization, improvement to senescence and loss of life. below physiological stipulations the power of proteases is regulated via endogenous inhibitors.

Biological Effects of Static Magnetic Fields

The publication summarizes the rising subject concerning the results of SMF on organic samples starting from unmarried molecules, subcellular booths, and cells to complete organisms, in addition to the capability program of SMF in medical remedy of melanoma and different ailments. With the advance and transforming into acclaim for smooth home equipment, together with MRI within the hospitals, the capability impression of magnetic fields on human healthiness is invoking expanding matters.

Extra resources for Cytochrome P450 2D6: Structure, Function, Regulation and Polymorphism

Sample text

Download PDF sample

Rated 4.01 of 5 – based on 25 votes